97211-31-9

Upstream product

• 57820-77-6 (-)-<1α,4α,7R*>-spirohept-5-ene-2,2'-<1,3>dioxolane>-7-methanol 
• 71155-12-9 methyl (-)-(1α,4α,5α,7S^*)-5-bromospiroheptane-2,2'-<1,3>dioxolane>-7-carboxylate 
• 97211-39-7 C₁₇H₂₀O₅S 
• 74778-89-5 (-)-5-bromospiroheptane-2,2'-<1,3>dioxolane>-7-methanol 

Relevant academic research and scientific papers

Fluoroprostaglandins: Totl Synthesis of (+)-13-Fluoroprostaglandin F2α Methyl Ester

(+)-13-Fluoroprostaglandin F2α methyl ester (1) was prepared from the readily available methyl (-)-(1α,4α,5α,7S*)-5-bromospiroheptane-2,2'-dioxolane>carboxylate (6).Construction of the 13-fluoro olefinic structural unit was achieved via a Schlosser-Wittig reaction employing chiral aldehyde 2 and chiral ylide 3. (+)-13-Fluoroprostaglandin F2α methyl ester was evaluated for pregnancy interruption in the hamster and smooth muscle stimulating properties on hamster uterine strips.