97221-16-4

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 156-43-4 4-Ethoxyaniline 

Downstream Products

• 62-44-2 4-ethoxyacetanilide 
• 555-16-8 4-nitrobenzaldehdye 
• 1150619-77-4 1-(4-ethoxyphenyl)-2-(4-nitrophenyl)spiro[azetidine-3,9'-xanthen]-4-one 
• 1444005-38-2 3-azido-1-(4-ethoxyphenyl)-4-(4-nitrophenyl)azetidin-2-one 
• 108979-59-5 6-ethoxy-2-(4-nitro-phenyl)-quinoline 

Relevant academic research and scientific papers

Synthesis of structurally diverse 2-azetidinones via staudinger reaction on a solid support

Trimellitic anhydride was attached to Merrifield resin and a ketene was generated from polymer-bound phthaloylglycine. Then this polymer reacted with imines in the presence of Vilsmeier reagent and triethylamine to afford the solid-phase-tethered β-lactam products. Selective cleavage of supported β-lactams by trifluoroacetic acid and methylhydrazine gave 4-carboxyphthalimido- and 3-amino-β-lactams, respectively. The trans-stereochemistry was found in all products.

GREEN SYNTHESIS OF ARYL ALDIMINES USING ETHYL LACTATE

The present invention relates to a method for preparing aryl aldimines. In particular, the present invention relates to methods of preparing aryl aldimines that uses environmentally friendly solvent systems.

The Vilsmeier reagent: a useful and versatile reagent for the synthesis of 2-azetidinones

(Chloromethylene)dimethylammonium chloride (Vilsmeier reagent), prepared easily from N,N-dimethylformamide and oxalyl chloride or thionyl chloride, works as a versatile acid activator reagent for the direct [2+2] ketene-imine cycloaddition of substituted

Synthesis of novel N-(4-ethoxyphenyl) azetidin-2-ones and their oxidative N-deprotection by ceric ammonium nitrate

It is shown that the N-(p-ethoxyphenyl) group on β-lactams can be oxidatively removed by ceric ammonium nitrate in good yield. Fourteen new N-(p-ethoxyphenyl)-2-azetidinones 8a-n were synthesized through standard [2+2] ketene-imine cycloadditions (Staudinger reaction). Treatment of these compounds with ceric ammonium nitrate yielded the N-dearylated 2-azetidinones 9a-n in good to excellent yields. The effects of solvent, molar equiv of CAN and different temperatures have been investigated and optimum conditions were established.

Thermodynamic Interpretation of the Terminal Group Effect on the Thermal Stability of a Mesophase

Nematic liquid crystal-isotropic liquid transition temperature-composition curves were calculated for the four binary systems between p-azoxyanisole and Shiff bases.The calculation was done by means of equal G analysis, which is one of the thermodynamic t