97222-18-9

Upstream product

• 89706-76-3 (1α,4α,5α,6β,7β)-4-carboxy-7-(phenylacetamido)-2-oxabicyclo<3.2.0>heptan-6-ol 
• 89706-75-2 (1α,4α,5α,6β,7β)-7-amino-4-benzyloxycarboxyl-2-oxabicyclo<3.2.0>heptan-6-ol cyclic carbamate 
• 103-80-0 phenylacetyl chloride 

Relevant academic research and scientific papers

Synthesis of a Cyclobutanone Analogue of a β-Lactam Antibiotic

A route has been developed which allows cyclobutanone analogues of β-lactam antibiotics to be synthesized and is illustrated by the synthesis of 6-oxo-7β-phenylacetamido-2-oxabicycloheptane-4α-carboxylic acid.Although this analogue (which contained some 7α-epimer) did not show significant antibacterial activity it was a weak inhibitor of Streptomyces R61 D,D-carboxypeptidase and a time-dependent inhibitor of E.coli R-TEM and B. cereus type I β-lactamases. 7β-Chloro-6-oxo-2-oxabicycloheptane-4α-carboxylic acid also exhibited time-dependent inhibition of these β-lactamases.