97259-48-8

Upstream product

• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 

Downstream Products

• 448963-34-6 {(S)-1-[(S)-4-({Amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-1-(4-hydroxymethyl-phenylcarbamoyl)-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 
• 448963-41-5 Carbonic acid 4-[(S)-5-({amino-[(E)-toluene-4-sulfonylimino]-methyl}-amino)-2-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-pentanoylamino]-benzyl ester 4-nitro-phenyl ester 

Relevant academic research and scientific papers

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.