97259-61-5Relevant academic research and scientific papers
Manganese-Catalyzed Direct Nucleophilic C(sp2)-H Addition to Aldehydes and Nitriles
Zhou, Bingwei,Hu, Yuanyuan,Wang, Congyang
supporting information, p. 13659 - 13663 (2015/11/16)
Herein, a manganese-catalyzed nucleophilic addition of inert C(sp2)-H bonds to aldehydes and nitriles is disclosed by virtue of a dual activation strategy. The reactions feature mild reaction conditions, excellent regio- and stereoselectivity, and a wide substrate scope, which includes both aromatic and olefinic C-H bonds, as well as a large variety of aldehydes and nitriles. Moreover, mechanistic studies shed light on possible catalytic cycles.
Iridium phosphite-oxazoline catalysts for the highly enantioselective hydrogenation of terminal alkenes
Mazuela, Javier,Verendel, J. Johan,Coll, Mercedes,Schaeffner, Benjamin,Boerner, Armin,Andersson, Pher G.,Pamies, Oscar,Dieguez, Montserrat
experimental part, p. 12344 - 12353 (2009/12/31)
A modular library of readily available phosphite-oxazoline ligands (L1-L16a-f) has been successfully applied for the first time in the Ir-catalyzed asymmetric hydrogenation of a broad range of highly unfunctionalized 1,1,-disubstituted terminal alkenes. Enantioselectivities up to >99% and full conversions were obtained in several 1,1-disubstituted alkenes, including substrate classes that have never been asymmetrically hydrogenated before (i.e., 1,1-heteoraryl-alkyl, 1,1-diaryl, trifluoromethyl, etc.). The results indicated that these catalytic systems have high tolerance to the steric and electronic requirements of the substrate and also to the presence of a neighboring polar group. The asymmetric hydrogenations were also performed using propylene carbonate as solvent, which allowed the Ir catalyst to be reused and maintained the excellent enantioselectivities.
