97280-35-8Relevant academic research and scientific papers
Folate Analogues. 26. Syntheses of Antifolate Activity of 10-Substituted Derivatives of 5,8-Dideazafolic Acid and of the Poly-γ-glutamyl Metabolites of N10-Propargyl-5,8-Dideazafolic Acid (PDDF)
Nair, M.G.,Nanavati, Nitin T.,Nair, Indira G.,Kisliuk, Roy L.,Gaumont, Y.,et al.
, p. 1754 - 1760 (2007/10/02)
The poly-γ-glutamyl derivatives of N10-propargyl-5,8-dideazafolic acid (PDDF) with a chain length of up to five glutamate residues were synthesized from N10-propargyl-5,8-dideazapteroic acid (7) by the solid-phase procedure.These com
Quinazoline Antifolates Inhibiting Thymidylate Synthase: Variation of the N10 Substituent
Jones, Terence R.,Calvert, A. Hilary,Jackman, Ann L.,Eakin, M. Allan,Smithers, Michael J.,et al.
, p. 1468 - 1476 (2007/10/02)
The synthesis of 12 new 5,8-dideazafolates with isopropyl, cyclopropylmethyl, 2-fluoroethyl, carbamoylmethyl, phenacyl, 3-fluorobenzyl, 5-uracilylmethyl, carboxymethyl, 2-carboxyethyl, 3-cyanopropyl, 3-hydroxypropyl, and cyanomethyl substituents at N
