97296-01-0Relevant academic research and scientific papers
Manganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones
Kong, Xianqiang,Xu, Bo
, p. 4495 - 4498 (2018/08/07)
An efficient manganese-catalyzed ortho-C-H amidation of weakly coordinating aromatic ketones using the readily available sulfonyl azide as the amination reagent is developed. The key step is the ketone directed aromatic metalation using the in situ generated reactive Mn intermediate, MnMe(CO)5. This method offers excellent chemical yields, high regioselectivities, and good functional group tolerance.
Transition-Metal-Free Decarboxylative Propargylic Substitution/Cyclization with either Azolium Enolates or Acyl Anions
Lu, Shenci,Ong, Jun-Yang,Poh, Si Bei,Tsang, Terence,Zhao, Yu
, p. 5714 - 5719 (2018/04/30)
Presented herein is an unprecedented transition-metal-free propargylic substitution reaction with either azolium enolates or acyl anions, which are generated from aldehydes under N-heterocyclic carbene catalysis. This new catalytic activation operates on readily available cyclic propargylic carbamates through decarboxylation, and generates reactive allene intermediates that can undergo divergent cyclization pathways to deliver skeletally diverse polycyclic compounds with high levels of efficiency and excellent enantioselectivities.
