97311-85-8Relevant academic research and scientific papers
The Influence of Steric Effects on the Selectivity of Radical CC Bond Formation Reactions
Giese, Bernd,Harnisch, Hanna,Luening, Ulrich
, p. 1345 - 1351 (2007/10/02)
Bulky substituents R1 and R2 at radical 5 decrease the rate of addition to diethyl fumarate to a larger extent than to methyl acrylate (Table 1).The comparison with H-abstraction, which is only slightly influenced by steric effects, shows that 5e (R2 = t-C4H9) reacts at least 235 times slower with diethyl fumarate than 5a (R2 = CH3) (Table 2).Therefore, the stereoselectivity of cyclic radicals 1 (n = 1,2) increases if the CC bond formation reaction is carried out with diethyl fumarate instead of methyl acrylate.
