97313-97-8Relevant academic research and scientific papers
Synthesis and Radioprotective Activity of New Cysteamine and Cystamine Derivatives
Oiry, J.,Pue, J. Y.,Imbach, J. L.,Fatome, M.,Sentenac-Roumanou, H.,Lion, C.
, p. 2217 - 2225 (2007/10/02)
A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.
