97315-38-3Relevant academic research and scientific papers
Selective Thromboxane Synthetase Inhibitors. 1. 1--1H-imidazoles
Cross, Peter E.,Dickinson, Roger P.,Parry, M. John,Randall, Michael J.
, p. 1427 - 1432 (2007/10/02)
1-(2-Phenoxyethyl)-1H-imidazole was found to be an inhibitor of thromboxane (TxA2) synthetase, but it also inhibited the adrenal cytochrome P-450 enzyme steroid 11β-hydroxylase.The preparation of a series of analogues is described, and activity against TxA2 synthetase, PGI2 synthetase, cyclooxygenase, and steroid 11β-hydroxylase is discussed.Potency against TxA2 synthetase was increased by introduction of a carboxyl group at a suitable distance from the imidazole ring.A distance of 8.1-8.8 Angstroem between N-1 of the imidazole and the carboxyl carbon was found to be optimal.Introduction of a carboxyl group also had the effect of reducing activity against steroid 11β-hydroxylase.The most potent and selective compound was found to be 4-benzoic acid (14).
NEW SYNTHETIC IONOPHORES EXHIBITING SELECTIVITY FOR ALKALINE EARTH METAL IONS
Taguchi, Kazuhiro,Hiratani, Kazuhisa,Sugihara, Hideki,Iio, Kokoro
, p. 1457 - 1460 (2007/10/02)
New noncyclic polyethers, which contain 3-carboxy-2-hydroxyphenyl group as one terminal group were prepared.These polyethers exhibit the ability to transport alkaline earth metal ions through chloroform liquid membrane, but not to transport alkali metal ions.Highly Ba++-selective ionophores were synthesized in this series.
