97322-88-8

Downstream Products

• 107187-66-6 t-Butyl α-{5-[4-(6-acetoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3yl}acetate 

Relevant academic research and scientific papers

Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation

A series of hindered phenols were investigated as hypolipidemic and/or hypoglycemic agents with ability to inhibit lipid peroxidation. 1,3-Benzoxathioles (9 and 22), phenoxypentanoic acid (34), phenoxypentanol (35a), phenoxynonanol (35b), phenylchloropropionic acid having a chromanyl group (25), and a thiazolidine compound (27) derived from 25, all having a hindered phenol group, were prepared and examined. Compound 27 showed the expected biological properties in vivo and in vitro without any liver weight increase. Biological activities of the analogous thiazolidine compounds, 43-58, were compared. Thus, roxy-2,5,7,8-tetramethylchroman-2-yl(methoxy]-benzyl]-2,4-thiazolidinedione (27) (CS-045) was found to have all our expected properties and was selected as a candidate for further development as a hypoglycemic and hypolipidemic agent.

Method for preventing and for treating autoimmune disease

A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.

Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism

The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and metabolic dysfunction, comprising the step of administering to a human determined to be susceptible to myocardial ischemia an effective amount of an insulin sensitizer; and (b) reducing hypertension comprising the step of administering to a hypertensive human determined to have normal insulin sensitivity, an effective amount of an insulin sensitizer. In a particular embodiment, the sensitizer comprises a thiazolidinedione compound, such as triglitazone.

Treatment and prophylaxis of pancreatitis

Insulin sensitizers, especially thiazolidinedione compounds, such as troglitazone, are useful for the treatment and prevention of pancreatitis.

Treatment and prophylaxis of osteoporosis

Compounds of formula (I): STR1 where R1, R2, R4 and R5 are hydrogen or alkyl and R3 is hydrogen, alkyl or various organic groups are effective against osteoporosis at doses at which they also effectively control diabetes.

Benzylidenethiazolidine derivatives and their use for the inhibition lipid peroxides

Benzylidenethiazolidine compounds of formula (I): STR1 [in which R1, R2 and R5 are each hydrogen or alkyl; R3 and R4 are each hydrogen, alkyl, formyl, alkylcarbonyl, arylcarbonyl, carboxy, alkoxycarbo

Thiazolidine derivatives, their preparation and compositions containing them

The compounds of formula (I): STR1 [in which: R1 and R2 are the same or different and each represents hydrogen or C1 -C5 alkyl; R3 represents hydrogen, an acyl group, a (C1 -C6 alkoxy)carbonyl group or an aralkyloxycarbonyl group; R4 and R5 are the same or different and each represents hydrogen, C1 -C5 alkyl or C1 -C5 alkoxy, or R4 and R5 together represent a C1 14 C4 alkylenedioxy group; n is 1, 2 or 3; W represents the --CH2 --, >CO or >CH--OR6 group (in which R6 represents any one of the atoms or groups defined for R3 and may be the same as or different from R3); and Y and Z are the same or different and each represents oxygen or imino] and pharmaceutically acceptable salts thereof have various valuable therapeutic effects on the blood system and may be prepared by a process which includes reacting a corresponding halopropionic acid derivative with thiourea.