97330-03-5Relevant academic research and scientific papers
Catalytic Regio- and Enantioselective Alkylation of Conjugated Dienyl Amides
Guo, Yafei,Kootstra, Johanan,Harutyunyan, Syuzanna R.
, p. 13547 - 13550 (2018/09/25)
A method for catalytic asymmetric alkylation of conjugated dienyl amides has been developed and it allows efficient and high-yielding transformations of a wide range of polyconjugated amides into the corresponding chiral products. Smooth addition of organomagnesium reagents to relatively unreactive dienyl amides with excellent 1,6- and 1,4-selectivities, as well as enantioselectivites above 90 %, is achieved owing to the complementary action of the Lewis acid and a chiral copper-based catalyst.
