97356-63-3Relevant academic research and scientific papers
Synthesis of enantiopure 1,4-dioxanes, morpholines, and piperazines from the reaction of chiral 1,2-diols, amino alcohols, and diamines with vinyl selenones
Bagnoli, Luana,Scarponi, Catalina,Rossi, Maria Giovanna,Testaferri, Lorenzo,Tiecco, Marcello
supporting information; experimental part, p. 993 - 999 (2011/03/20)
The reactions of readily available vinyl selenones with enantiopure 1,2-diols, N-protected-1,2-aminoalcohols, and diamines gave substituted enantiopure 1,4-dioxanes, morpholines, and piperazines, respectively, in good to excellent yields. The same procedu
Bromoethylsulfonium salt-a more effective annulation agent for the synthesis of 6- and 7-membered 1,4-heterocyclic compounds
Yar, Muhammad,McGarrigle, Eoghan M.,Aggarwal, Varinder K.
supporting information; experimental part, p. 257 - 260 (2009/08/08)
(Chemical Equation Presented) Reaction of bromoethylsulfonium salt with 1,2-/1,3-aminoalcohols gave six- and seven-membered rings in good-to-excellent yields. The reactions proceed through generation of a vinyl sulfonium salt followed by annulation to give 1,4-heterocyclic compounds such as morpholines and benzoxazepines in a simple procedure. The method accommodates a range of nitrogen substituents and the amino alcohol can be substituted by amino thiols and diamines to give thiomorpholines, piperazines and benzodiazepines.
