97371-26-1

Upstream product

• 880258-24-2 N^α-((Ξ)-2-bromo-4-methyl-valeryl)-L-histidine 
• 910890-97-0 N^α-((Ξ)-2-bromo-4-methyl-valeryl)-L-histidine-methyl ester 
• 1499-46-3 L-Histidine methyl ester 
• 28659-88-3 2-bromo-4-methylpentanoyl chloride 

Downstream Products

• 61-90-5 L-leucine 
• 71-00-1 L-histidine 

Relevant academic research and scientific papers

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.