97409-50-2

Upstream product

• 97466-19-8 (S)-pyrrolidine-2-carboxylic acid isopropyl ester hydrochloride 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 103383-78-4 (R)-(-)-3-hydroxy-3-phenyl-hex-5-en-2-one 
• 103383-79-5 (S)-(+)-3-hydroxy-3-phenyl-5-hexen-2-one 
• 103383-75-1 (S)-1-(2-Hydroxy-2-phenyl-pent-4-enoyl)-pyrrolidine-2-carboxylic acid isopropyl ester 

Relevant academic research and scientific papers

Diastereoselective Reduction of Chiral α-Ketoamides Derived from (S)-Proline Esters with Sodium Borohydride. Preparation of Optically Active α-Hydroxy Acids

Diastereoselective reductions of chiral α-ketoamides (3) derived from (S)-proline esters (2) with sodium borohydride were examined.Hydrolysis of the reduction products afforded optically active α-hydroxy acids (5) in good enantiomeric excesses (e.e.).The most influential factor of the asymmetric induction was the effect of using a mixed hydroxylic and non-hydroxylic solvent.The degree of asymmetric induction varied considerably with the ratio of alcohol and tetrahydrofuran (THF) in the mixed solvent.With aromatic ketoamides (3), higher asymmetric induction occured in a mixed alcohol-THF solvent than in the corresponding individual solvents.