97459-72-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-methoxy-4-nitrophenyl)morpholine is used as an intermediate in the synthesis of pharmaceuticals for its versatile chemical properties and potential biological activity.
Used in Agrochemical Industry:
4-(2-methoxy-4-nitrophenyl)morpholine also serves as an intermediate in the synthesis of agrochemicals, contributing to the development of products for agricultural applications.
Used in Neurodegenerative Disease Research:
4-(2-methoxy-4-nitrophenyl)morpholine is used as a research compound for studying its potential as an inhibitor of acetylcholinesterase, an enzyme implicated in neurodegenerative diseases like Alzheimer's, with the aim of developing treatments that can slow disease progression or improve symptoms.

InChI:InChI=1/C11H14N2O4/c1-16-11-8-9(13(14)15)2-3-10(11)12-4-6-17-7-5-12/h2-3,8H,4-7H2,1H3

Upstream product

• 110-91-8 morpholine 
• 709-09-1 3,4-dimethoxynitrobenzene 
• 1009-36-5 2-chloro-5-nitroanisole 
• 454-16-0 1-fluoro-2-methoxy-4-nitrobenzene 
• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 865-48-5 sodium t-butanolate 

Downstream Products

• 482308-06-5 3-methoxy-4-morpholin-4-yl-phenylamine 
• 1574541-74-4 (±)-3-bromo-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one 
• 1574538-35-4 (±)-3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one 
• 1574538-36-5 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one 
• 1574538-37-6 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

A class of FLT3 kinase inhibitors, preparation and application thereof

The invention relates to a class of FLT3 kinase inhibitors, preparation and application thereof, wherein specifically the compound has a structure represented by a formula (I), and all groups and substituents are defined in the specification. The invention also discloses a preparation method of the compound, and application of the compound in inhibition of FLT3.

QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF

Compounds and methods for their preparation and use as therapeutic or prophylactic agents, fo example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase- 1 (ENPP1).

Imidazopyridazine IRAK4 inhibitor, and preparation method and application thereof

The invention belongs to the field of medicines, and especially relates to an imidazopyridazine compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and an applicationof a medicinal composition of the compound or the salt in the treatment of tumors, inflammations, immunity and other diseases. The imidazopyridazine compound is a novel protein kinase IRAK4 inhibitor, and can selectively inhibit IRAK4 and downstream signaling pathways thereof. The compound has the structural formula I.

PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments.

IMIDAZOPYRAZINE SYK INHIBITORS

Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suf-fering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of an imidazopyrazine compound effective to reduce signs or symptoms of the disease or dis-order are provided.

Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors

The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, w

4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R1, q, p, R2, t, Ar1, L1, R3 and R4 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS

Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.

Amino-substituted pyrimidinyl derivatives and methods of use

The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.