97476-52-3Relevant academic research and scientific papers
PYRROLE STUDIES. PART 32. A NOVEL RING-CLEAVAGE REACTION OF THE PYRIDAZINE RING DURING THE REACTION OF 6H-PYRROLOPYRIDAZINES WITH DIMETHYL ACETYLENEDICARBOXYLATE
Hernandez, Teresa de la Figuera Gom,ez,Arques, Sepulveda Jose,Jones, R. Alan,Dawes, Helen M.,Hursthouse, Michael B.
, p. 899 - 902 (2007/10/02)
The reaction of 6H-pyrrolopyridazines with dimethyl acetylenedicarboxylate in methanol leads initially to (1,2-dihydro-1-methoxy-6H-pyrrolopyridazin-2-yl)fumaric esters, which are unstable in the presence of water and undergo a ring-cleavage reaction to yield 4,5-diaza-6-pyrrol-3-ylhexa-3,5-dienoates.The structure of the 4-formyl-2,5-dimethylpyrrol-3-yl derivative has been confirmed by X-ray crystallography.
