97485-05-7Relevant academic research and scientific papers
SYNTHESIS OF NEW BRANCHED POLYPEPTIDES WITH POLY(LYSINE)BACK BONE
Hudecz, Ferenc,Szekerke, Maria
, p. 103 - 113 (2007/10/02)
New analogues of branched polypeptides were synthesised for a further, more detailed study of the influence of the side chain terminating amino acids, particularly the hydrophobic character, configuration and the number of these amino acids, on the conformation and biological properties of the polymers.The folowing amino acids were coupled to poly(L-Lys-(DL-Alam)) in suitably protected and activated forms to study the above mentioned aspects: L-Nle, L-Ile, L-Val, L-Phe, D-Phe, D-Leu, D-Tyr, D-His, L-Glu, D-Glu, L-Lys, D-Lys and additionally the L-Glu-L-Glu, D-Glu-D-Glu, L-Lys-L-Lys and D-Lys-D-Lys dipeptides.The protected and purified end products were freezedried and characterized by various methods.
