97521-30-7

Basic information

• Product Name: N-carboxy Boc-Leu-ΔPhe anhydride
• Synonyms: N-carboxy Boc-Leu-ΔPhe anhydride
• CAS NO: 97521-30-7
• Molecular Weight: 402.447
• Mol File: 97521-30-7.mol

Chemical Properties

• CAS DataBase Reference: N-carboxy Boc-Leu-ΔPhe anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: N-carboxy Boc-Leu-ΔPhe anhydride(97521-30-7)
• EPA Substance Registry System: N-carboxy Boc-Leu-ΔPhe anhydride(97521-30-7)

Safety Data

• Hazardous Substances Data: 97521-30-7(Hazardous Substances Data)

Upstream product

• 193069-45-3 Boc-Leu-ΔLeu-Leu-OMe 
• 193069-44-2 Boc-Leu-ΔLeu-Val-OMe 
• 193069-43-1 Boc-Leu-ΔLeu-Gly-OMe 
• 108450-83-5 Boc-L-Leu-(Z)-ΔLeu*NCA 
• 108460-59-9 Boc-L-Leu-(Z)-ΔLeu-L-Ala-OMe 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 74805-42-8 N-carboxy-α-dehydrophenylalanine anhydride 

Downstream Products

• 119767-96-3 Boc-L-Leu-(Z)-ΔPhe-L-Ala-OMe 
• 119767-94-1 Boc-L-Ala-L-Leu-(Z)-ΔPhe-OMe 
• 123975-76-8 Boc-L-Leu-L-Phe-L-Ala-OMe 
• 123975-76-8 Boc-L-Leu-D-Phe-L-Ala-OMe 
• 23234-27-7 (6S,9S,12S)-methyl 12-benzyl-9-isobutyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate 
• 123975-73-5 Boc-L-Ala-L-Leu-D-Phe-OMe 
• 117833-86-0 H-L-Leu-(Z)-ΔPhe-OMe 
• 74124-69-9 (3Z,6S)-3-benzylidene-6-isobutylpiperazine-2,5-dione 
• 108432-44-6 Boc-Leu-Δ^ZPhe-OH 
• 119767-94-1 Boc-A-(D)-L-ΔF-OMe 
• 117833-86-0 (E)-2-((R)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-acrylic acid methyl ester 

Relevant articles and documents

Dehydrooligopeptides. XX. Unusual Peptide Bond Cleavage of Dehydrotripeptide Esters Containing α-Dehydroamino Acid Residue at P2 by Using Papain

Enzymatic ester hydrolysis and coupling of various N- protected Δ2 - dehydrotripeptide methyl esters (Boc-AA-ΔAA-AA-OMe) (4) by using protease papain in Mcllvaine buffer are mainly described. The substrates (4) used were prepared by one-pot coupling of N-carboxy-α-dehydroamino acid anhydride (ΔAA·NCA) with N- and C-component L-α-amino acids (AA). Even in the enzymatic reaction of 4 containing an unusual ΔAA residue, the normal ester hydrolysis took place to give Boc-AA-ΔAA-AA-OH (6) and, in certain cases, the interesting unusual peptide bond cleavage at P2 of 6 occured further to give the unexpected N-(1,2-dioxoalkyl)-AA-OH. Besides examining in detail the differences between the enzymatic actions to the structures of 4, we also studied the mechanisms of the ester and peptide bond hydrolyses. As the results, the reverse enzymatic coupling of 4 with H-AA-ΔVal-OMe was first achieved to give dehydropentapeptide containing two ΔAA residues.

Dehydrooligopeptides. XIV. Convenient Coupling of N-Carboxy-α-dehydroamino Acid Anhydride with Both Amine and Carboxyl Components

In order to further develop and expand the usefulness of N-carboxy-α-dehydroamino acid anhydride (ΔNCA), the optimum conditions of the acylation of ΔNCA with N-protected α-amino acids (AA) were thoroughly examined.Furthermore, various kinds of AA or dipep

Correlation between the Configurational Structure and the Asymmetric Hydrogenation of Δ1-, Δ2-, and Δ3-Dehydrotripeptides

The heterogeneous catalytic hydrogenation of Δ1-dehydrotripeptides (Δ1-DHP), which have a β-turn structure, was carried out to give the corresponding tripeptides indicative of the very large diastereomeric excess, comparing with thos

A NEW ROUTE TO (Z)-3-ALKYLIDENE-(S)-6-ALKYL-2,5-PIPERAZINEDIONES VIA N-CARBOXY-α-DEHYDROAMINO ACID ANHYDRIDES

A new synthetic method for (Z)-3-alkylidene-(S)-6-alkyl-2,5-piperazinediones was accomplished by the coupling of N-carboxy-α-dehydroamino acid anhydrides with Boc-α-amino acid, followed by the deprotection of Boc group and by the ring expansion.