97541-76-9

Upstream product

• 57343-53-0 6-<(p-carbethoxybenzyl)amino>-5-chloro-2,4-diaminoquinazoline 
• 17511-20-5 5-chloro-2,4,6-triaminoquinazoline 
• 108947-94-0 6-<(p-carbethoxybenzylidene)amino>-5-chloro-2,4-diaminoquinazoline 
• 6287-86-1 p-ethoxycarbonylbenzaldehyde 

Downstream Products

• 143745-32-8 2-amino-6-<(p-carboxybenzyl)amino>-5-chloro-quinazoline-4(3H)-one 
• 108947-97-3 di-tert-butyl 5-chloro-5,8-dideazaisofolate 
• 108947-93-9 (S)-2-{4-[(2,4-Diamino-5-chloro-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid 
• 108947-92-8 (S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid 

Relevant academic research and scientific papers

Synthesis of 5-chloro-5,8-dideaza analogues of folic acid and aminopterin targeted for colon adenocarcinoma

Several classical quinazoline analogues of folic acid bearing chloro or methyl substituents at position 5 were evaluated as inhibitors of the growth of four human gastrointestinal adenocarcinoma cell lines in vitro. The preparation of two of these, 5-chlo