97545-40-9Relevant academic research and scientific papers
Reductive Ni-catalysis for stereoselective carboarylation of terminal aryl alkynes
Maiti, Saikat,Rhlee, Joon Ho
supporting information, p. 11346 - 11349 (2021/11/09)
Stereoselective dicarbofunctionalization of terminal aryl alkynes has been achieved through reductive Ni-catalysis. The exclusive regioselective andanti-addition selective alkylarylation of terminal alkynes is accomplished using alkyl iodide and aryl iodide as electrophilic coupling partners in the presence of NiBr2as the catalyst and Mn as an inexpensive reductant.
Palladium-Catalyzed γ,γ′-Diarylation of Free Alkenyl Amines
Fu, Yu,Grant, Aaron J.,Landge, Vinod G.,Payton, John L.,Rabon, Allison M.,Young, Michael C.
supporting information, p. 10352 - 10360 (2021/07/26)
The direct difunctionalization of alkenes is an effective way to construct multiple C-C bonds in one-pot using a single functional group. The regioselective dicarbofunctionalization of alkenes is therefore an important area of research to rapidly obtain complex organic molecules. Herein, we report a palladium-catalyzed γ,γ′-diarylation of free alkenyl amines through interrupted chain walking for the synthesis of Z-selective alkenyl amines. Notably, while 1,3-dicarbofunctionalization of allyl groups is well precedented, the present disclosure allows 1,3-dicarbofunctionalization of highly substituted allylamines to give highly Z-selective trisubsubstituted olefin products. This cascade reaction operates via an unprotected amine-directed Mizoroki-Heck (MH) pathway featuring a β-hydride elimination to selectively chain walk to furnish a new terminal olefin which then generates the cis-selective alkenyl amines around the sterically crowded allyl moiety. This operationally simple protocol is applicable to a variety of cyclic, branched, and linear secondary and tertiary alkenylamines, and has a broad substrate scope with regard to the arene coupling partner as well. Mechanistic studies have been performed to help elucidate the mechanism, including the presence of a likely unproductive side C-H activation pathway.
Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters
Van Dort,Schwendner,Skinner,Gross,Counsell
, p. 85 - 93 (2007/10/02)
A series of radioiodinated pregnenolone esters was prepared in an effort to find an agent that would be rapidly and selectively taken up by adrenal cortical tissue. Achievement of such a goal would provide the basis for the development of an adrenal imagi
