97554-76-2

Basic information

• Product Name: 2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester
• Synonyms: 2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester
• CAS NO: 97554-76-2
• Molecular Weight: 342.329
• Mol File: 97554-76-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester(97554-76-2)
• EPA Substance Registry System: 2-(diethoxyphosphoryl)-4-oxo-4-phenylbutyric acid ethyl ester(97554-76-2)

Safety Data

• Hazardous Substances Data: 97554-76-2(Hazardous Substances Data)

Upstream product

• 1008788-80-4 2-(diethoxyphosphoryl)-3-(2-phenyl-[1,3]dioxolan-2-yl)-propionic acid ethyl ester 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 15121-89-8 ethyl 3-benzoyl acrylate 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 1027102-74-4 4-iethoxyphosphoryl-2,6-diphenylpyridazin-3(2H)-one 
• 1037575-77-1 3-diethoxyphosphoryl-1-methyl-5-phenylpyrrolidin-2-one 
• 1008788-92-8 (2-oxo-5-phenyltetrahydrofuran-3-yl)-phosphonic acid diethyl ester 
• 266001-35-8 4-diethoxyphosphoryl-6-phenylpyridazin-3(2H)-one 

Relevant articles and documents

A general stereoselective method for the synthesis of cyclopropanecarboxylates. A new version of the homologous Horner-Wadsworth- Emmons reaction

The synthesis of α-, β- and γ-substituted α-phosphono-γ-lactones was accomplished using different ring closure and ring homologation strategies. It was found that the lactones could be selectively transformed into the corresponding ethyl cyclopropanecarboxylates by treatment with sodium ethoxide in boiling THF. The reported reaction provides an attractive alternative to the classical homologous Horner-Wadsworth-Emmons approach to the construction of cyclopropanes with electron-withdrawing functionalities. This journal is The Royal Society of Chemistry.

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Diethylphosphite and p-chlorodiphenylphosphine react with β-acylacrylates to give γ,β′-ketoesterphosphonates 2 and 2′. When reacted with 2-ene-1,4-diones, in the same conditions, p-chlorodiphenylphosphine leads directely to 3-(diphenylphosphineoxide)-fura