97589-58-7

Upstream product

• 591-50-4 iodobenzene 
• 1257204-45-7 (S)-(-)-2,2,2-trifluoro-1-(2-(iodomethyl)pyrrolidin-1-yl)ethanone 
• 186202-18-6 (S)-(-)-2,2,2-trifluoro-1-(2-(hydroxymethyl)pyrrolidin-1-yl)ethanone 
• 71-43-2 benzene 
• 36724-68-2 (S)-N-trifluoroacetylproline acid chloride 
• 97589-54-3 (S)-1-(2-benzoylpyrrolidin-1-yl)-2,2,2-trifluoroethan-1-one 

Downstream Products

• 97522-31-1 (+)-2-(S)-benzylpyrrolidine 

Relevant academic research and scientific papers

In situ trapping of Boc-2-pyrrolidinylmethylzinc iodide with aryl iodides: Direct synthesis of 2-benzylpyrrolidines

Addition of (S)-(+)-tert-butyl 2-(iodomethyl)pyrrolidine-1-carboxylate to activated zinc, aryl halides, and a catalyst derived from Pd2(dba) 3 (2.5 mol %) and SPhos (5 mol %) in DMF allows trapping of the corresponding organozinc rea

N-(Trifluoroacetyl)-α-amino Acid Chlorides as Chiral Reagents for Friedel-Crafts Synthesis

Chiral N-(trifluoroacetyl)-α-amino acid chlorides unergo Friedel-Crafts reaction with benzene and 1,2-dimethoxybenzene under mild conditions commonly with complete (>99percent) preservation of configurational identity.The resultant (trifluoroacetyl)amino ketones may be deoxygenated with Et3SiH or H2/Pd-C in acidic media to the corresponding N-(trifluoroacetyl)-β-arylalkylamines likewise without loss of configurational purity.