97603-39-9

Usage

Uses

Used in Organic Synthesis:
4-chloro-2-pyridin-3-ylpyrimidine is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-chloro-2-pyridin-3-ylpyrimidine is utilized as an intermediate in the development of new drugs. Its chemical properties make it a valuable component in the synthesis of medicinal compounds with potential therapeutic effects.
Used in Chemical Tools for Biological Studies:
4-chloro-2-pyridin-3-ylpyrimidine also serves as a chemical tool in the study of biological processes. Researchers use 4-chloro-2-pyridin-3-ylpyrimidine to probe and understand complex biological mechanisms, which can lead to advancements in medicine and biology.
Used in Agrochemical Production:
Furthermore, 4-chloro-2-pyridin-3-ylpyrimidine is a component in the production of herbicides and pesticides. Its incorporation into these products contributes to their effectiveness in controlling weeds and pests, thereby supporting agricultural productivity.
Overall, 4-chloro-2-pyridin-3-ylpyrimidine's diverse applications across organic chemistry, pharmaceuticals, and agrochemicals highlight its importance and value in these fields.

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 7356-60-7 pyridine-3-carboxamidine hydrochloride 
• 97604-06-3 2-(pyridin-3-yl)pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

In an effort to identify an HIV-1 capsid assembly inhibitor with improved solubility and potency, we synthesized two series of pyrimidine analogues based on our earlier lead compound N-(4-(ethoxycarbonyl)phenyl)-2-(pyridine-4-yl)quinazoline-4-amine. In vitro binding experiments showed that our series of 2-pyridine-4-ylpyrimidines had IC50values higher than 28 μM. Our series of 2-pyridine-3-ylpyrimidines exhibited IC50values ranging from 3 to 60 μM. The congeners with a fluoro substituent introduced at the 4-N-phenyl moiety, along with a methyl at C-6, represent potent HIV capsid assembly inhibitors binding to the C-terminal domain of the capsid protein.

COMPOUNDS FOR USE IN INHIBITING HIV CAPSID ASSEMBLY

The present invention relates a compound or a pharmaceutically acceptable salt or solvate thereof for use in inhibiting HIV capsid assembly, wherein the compound is a pyrimidine being at least substituted in two positions, preferably in 2 and 4 position o

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.