97618-99-0Relevant academic research and scientific papers
A facile synthesis of β-amino carbonyl compounds through an aza-Michael addition reaction under solvent-free conditions
Huang, Chao,Yin, Yanqing,Guo, Jiahui,Wang, Jiong,Fan, Baomin,Yang, Lijuan
, p. 10188 - 10195 (2014/03/21)
An efficient and eco-friendly process for the synthesis of β-amino carbonyl compounds was introduced in this paper. The oxanorbornene β-amino esters and β-enamine esters were successfully prepared from oxabornene and amines by using solvent-free aza-Michael addition reaction in the absence of any catalyst. Oxanorbornene β-amino esters were the major product at room temperature, but higher temperature (e.g. 90 °C) led to the formation of β-enamine esters. In addition, all of the target compounds were characterized by IR, 1H NMR, 13C NMR, and HR-MS. A possible reaction pathway was also proposed.
Practical synthesis and mechanistic study of polysubstituted tetrahydropyrimidines with use of domino multicomponent reactions
Zhu, Qiuhua,Jiang, Huanfeng,Li, Jinghao,Zhang, Min,Wang, Xiujun,Qi, Chaorong
scheme or table, p. 4604 - 4613 (2009/10/02)
The practical synthesis of polysubstituted tetrahydropyrimidines 4 from but-2-ynedioates 1, amines 2, and formaldehyde 3 through a domino process of one-pot multicomponent reactions (MCRs) and the detailed mechanistic studies are described. The MCRs were
