2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one, also known as 6-mercaptopurine arabinoside or thioguanine arabinoside, is a chemotherapeutic agent used in the treatment of various types of cancer, particularly acute lymphoblastic leukemia and acute myeloid leukemia. 2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one is a prodrug, meaning it is metabolized in the body to produce the active form of the drug, 6-mercaptopurine. The chemical structure consists of a pyrimidine ring with a 4(1H)-one functional group, a 4-aminobenzenesulfonylamino group at the 2-position, and a β-D-arabinofuranosyl group at the 1-position. The arabinofuranosyl group is a modified sugar molecule that enhances the drug's solubility and bioavailability, allowing it to be more effectively absorbed and utilized by the body. The mechanism of action involves the inhibition of DNA synthesis and the incorporation of the active metabolite into DNA, leading to the disruption of DNA function and ultimately cell death.
97626-02-3
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Basic information
- Product Name: 2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one
- Synonyms:
- CAS NO:97626-02-3
- Molecular Formula:
- Molecular Weight: 398.397
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one(CAS DataBase Reference)
- NIST Chemistry Reference: 2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one(97626-02-3)
- EPA Substance Registry System: 2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one(97626-02-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 97626-02-3(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 97626-02-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,6,2 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.Calculate Digit Verification of CAS Registry Number 97626-02:
(7*9)+(6*7)+(5*6)+(4*2)+(3*6)+(2*0)+(1*2)=163
163 % 10 = 3
So 97626-02-3 is a valid CAS Registry Number.
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2-(4-Aminobenzenesulfonylamino)-1-(1-β-D-arabinofuranosyl)pyrimidin-4(1H)-one
