97630-01-8

Usage

Chemical class

Piperazine sulfonamide derivative
This classification indicates that the compound is derived from piperazine, a heterocyclic amine, and contains a sulfonamide functional group.

Structural features

Contains a piperazine ring and a trifluoromethylphenyl group
The piperazine ring is a six-membered nitrogen-containing ring, and the trifluoromethylphenyl group is a phenyl group (a six-membered carbon ring with alternating single and double bonds) with a trifluoromethyl (CF3) substituent.

Potential pharmaceutical properties

Investigated for use in the development of drugs for various medical conditions
This suggests that the compound has been studied for its possible therapeutic effects and could be a candidate for further research in the pharmaceutical industry.

Research and development

Potential candidate for further research and development in the pharmaceutical industry
Given its unique structure and potential pharmaceutical properties, 1-[[3-(TRIFLUOROMETHYL)PHENYL]SULFONYL]PIPERAZINE may be a valuable compound for the development of new drugs and therapies.

Applications

Possible use in the treatment of various medical conditions
While the specific conditions are not mentioned in the material provided, the compound's potential pharmaceutical properties suggest that it could be relevant to a range of medical applications.

Upstream product

• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 
• 1219624-80-2 tert-butyl 4-(3-(trifluoromethyl)phenylsulfonyl)piperazine-1-carboxylate 
• 110-85-0 piperazine 

Relevant academic research and scientific papers

Discovery of Novel Chromone Derivatives Containing a Sulfonamide Moiety as Anti-ToCV Agents through the Tomato Chlorosis Virus Coat Protein-Oriented Screening Method

A number of novel chromone derivatives containing sulfonamide moieties were designed and synthesized, and the activity of compounds against tomato chlorosis virus (ToCV) was assessed using the ToCVCP-oriented screening method. Comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models were established based on the dissociation constant (Kd) values of the target compounds, and compound 35 was designed and synthesized with the aid of CoMFA and CoMSIA models. The study of affinity interaction indicated that compound 35 exhibited excellent affinity with ToCVCP with a Kd value of 0.11 μM, which was better than that of the positive control agents xiangcaoliusuobingmi (0.44 μM) and ningnanmycin (0.79 μM). In addition, the in vivo inhibitory effect of compound 35 on the ToCVCP gene was evaluated by the quantitative real-time polymerase chain reaction. ToCVCP gene expression levels of the compound 35 treatment group were reduced by 67.2%, which was better than that of the positive control agent ningnanmycin (59.5%). Therefore, compound 35 can be used as a potential anti-ToCV drug in the future.

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. ory

Myricetin derivative containing sulfonyl piperazine as well as preparation method and application thereof

The invention discloses a myricetin derivative containing sulfonyl piperazine as well as a preparation method and application of the myricetin derivative. The structural general formula of the myricetin derivative is shown in the specification, and n is t