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2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride, also known as Latrepirdine, is a synthetic compound with a complex chemical structure. It was initially developed as an antihistamine drug in Russia. However, recent research has revealed its potential to exhibit neuroprotective and anti-amnesic properties, making it a promising candidate for the treatment of neurodegenerative conditions.

97657-92-6

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97657-92-6 Usage

Uses

Used in Neurodegenerative Applications:
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride is used as a neuroprotective agent for the treatment of neurodegenerative conditions such as Alzheimer's disease. It has been shown to target the mitochondria and restore mitochondrial function, leading to improved neuronal survival and reduced oxidative stress. Additionally, it has demonstrated anti-amnesic properties, potentially improving memory and cognitive function in patients with neurodegenerative disorders.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride is used as a drug candidate for the development of novel therapeutic agents targeting neurodegenerative conditions. Its unique properties and potential to modulate mitochondrial function make it a valuable compound for further research and development in the field of neurodegenerative disease treatment.

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT 6 and 5-HT 7 ), α -adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β -amyloid fragment.

Check Digit Verification of cas no

The CAS Registry Mumber 97657-92-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,6,5 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 97657-92:
(7*9)+(6*7)+(5*6)+(4*5)+(3*7)+(2*9)+(1*2)=196
196 % 10 = 6
So 97657-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H25N3.ClH/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;/h4-7,12-13H,8-11,14H2,1-3H3;1H

97657-92-6 Well-known Company Product Price

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  • Sigma

  • (D6196)  Dimebon dihydrochloride hydrate  ≥98% (HPLC)

  • 97657-92-6

  • D6196-5MG

  • 1,208.61CNY

  • Detail
  • Sigma

  • (D6196)  Dimebon dihydrochloride hydrate  ≥98% (HPLC)

  • 97657-92-6

  • D6196-25MG

  • 4,836.78CNY

  • Detail

97657-92-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole,dihydrochloride

1.2 Other means of identification

Product number -
Other names Dimebon,Latrepirdine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:97657-92-6 SDS

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