97678-08-5Relevant academic research and scientific papers
Research on heterocyclic compounds. XVI. 2-Methylimidazo[1,2-a]pyrazine-3-carboxylic acids
Abignente,Arena,De Caprariis,et al.
, p. 79 - 85 (2007/10/02)
A group of 2-methylimidazo[1,2-a]pyrazine-3-carboxylic acids bearing various substituents on the pyrazine ring was synthesized by the reaction of a 2-aminopyrazine with ethyl 2-chloroacetoacetate; the ethyl carboxylates so obtained gave the corresponding acids by hydrolysis. The mechanism of this synthesis was discussed. Antiinflammatory and related pharmacological activities of these carboxylic acids were compared with indomethacin.
