97678-51-8Relevant academic research and scientific papers
PROCESS FOR PREPARING (R)-3,4-EPOXY-1-BUTANOL
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Page/Page column 7, (2008/06/13)
The present invention relates to a novel process for preparing (R)-3,4-epoxy-1-butanol in particular, a process for preparing (R)-3,4-epoxy-1-butanol with relatively high yield and in a cost-effective manner, wherein (S)-3-alkyl or arylsulfonyloxy-butyrolactone used as a starting material is reduced under a mild condition to give 2-alkyl or arylsulfonyloxy-1,4-butanediol as an intermediate, and the intermediate is then epoxidized in the presence of a base to invert a chiral center.
ASYMMETRIC MICHAEL ADDITION OF THIOPHENOL TO MALEIC ACID ESTERS
Yamashita, Hiroyuki,Mukaiyama, Teruaki
, p. 363 - 366 (2007/10/02)
(S)-(-)-Diisopropyl phenylthiosuccinate (81percent optical purity) is prepared in 95percent yield by the asymmetric Michael addition of thiophenol to diisopropyl maleate in the presence of a catalytic amount of cinchonine.The succinate thus prepared is transformed into (R)-(+)-3,4-epoxy-1-butanol without racemization.
