97704-16-0

Upstream product

• 1120-72-5 2-Methylcyclopentanone 
• 106-38-7 para-bromotoluene 

Downstream Products

• 97023-74-0 1-(4-methylphenyl)-hexane-1,5-dione 
• 364603-07-6 4-methylphenyl-2-methylcyclopentane oxide 
• 364603-08-7 2-(4-methylphenyl)-1,2-dimethylcyclopentanol 
• 16982-00-6 1-(1,2,2-trimethylcyclopentyl)-4-methylbenzene 

Relevant academic research and scientific papers

Natural products via reetz chemistry synthesis of (±)-cuparene

A concise synthesis of (±)-cuparene via Grignard, trimethylaluminum and dimethyltitanium dichloride (Reetz Alkylation) reactions to form the quaternary centers of (±)-cuparene is reported.

Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents

We report the first terminal trifluoromethylation at aryl and alkyl ketones' ?, or more remote sites via the selective C-C bond cleavage of cycloalkanols. The noncovalent interactions between alcohols and hypervalent iodines(III) reagents were disclosed to activate both alcohols and the Togni I reagent in the dual photoredox/copper catalysis for the transformation. This reaction was scalable to the gram-scale synthesis, applicable to the structurally complex steroid trifluoromethylation, and extendable to the pentafluoroethylation.