97749-78-5Relevant academic research and scientific papers
Highly efficient, environment-friendly, one-pot synthesis of 2-substituted 4-formylimidazoles from 4-acylaminoisoxazoles
Gao, Feng,Tian, Xin-Chuan,Qu, Xiao-Xia,Wang, Dan,Pu, Dong
, p. 65 - 70 (2015/02/18)
A highly efficient and environment-friendly one-pot synthesis of 2-substituted 4-formylimidazoles was accomplished. Raney nickel catalyzed hydrogenation of 4-acylaminoisoxazoles in ethanol, followed by sodium hydroxide promoted recyclization of the ring-opened intermediates, afforded the functionalized imidazoles.
Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones
Dhainaut, Alain,Tizot, André,Raimbaud, Eric,Lockhart, Brian,Lestage, Pierre,Goldstein, Solo
, p. 2165 - 2175 (2007/10/03)
A new series of imidazolyl nitrones spin traps has been synthesized and evaluated pharmacologically. The salient structural feature of these molecules is the presence of an imidazole moiety substituted by aromatic or heteroaromatic cycles. This connectivi
Imidazotriazines as Potential Antiasthma Agents
Paul, Rolf,Brockman, John A.,Hallett, W. A.,Hanifin, John W.,Tarrant, M. Ernestine,et al.
, p. 1704 - 1716 (2007/10/02)
By using inhibition of histamine release from antigen-challenged, sensitized human basophils as a means of identifying a potentialy prophylactic drug for the treatment of asthma, a series of substituted imidazotriazines were found, which wer
