97760-41-3Relevant academic research and scientific papers
Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries
Stivala, Craig E.,Zakarian, Armen
supporting information; experimental part, p. 11936 - 11939 (2011/09/19)
A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.
