97767-31-2Relevant academic research and scientific papers
Benzamidomethylation with (benzamidomethyl)triethylammonium chloride. 2. A simple method for benzamidomethylation of thiols, amines and carboxylic acids
Popovski, Emil,Klisarova, Ljiljana,Vikic-Topic, Drazen
, p. 927 - 936 (2007/10/03)
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl)amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH 2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane.
