97798-09-9Relevant academic research and scientific papers
AKT PROTEIN KINASE INHIBITORS
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, (2008/06/13)
The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Synthesis of 2-Arylsuccinates by Oxidative 1,2-Aryl Migration of 3-Aroylpropionic Acids or 5-Arylfuran-2(3H)-ones with Thallium(III) Nitrate
Tamura, Yasumitsu,Shirouchi, Yoshiaki,Minamikawa, Jun-ichi,Haruta, Jun-ichi
, p. 551 - 556 (2007/10/02)
Treatment of 3-aroylpropionic acids (1) with thallium(III) nitrate causes smooth 1,2-aryl migration to give dimethyl 2-arylsuccinates (2) in good yields.Similar transformation of 5-arylfuran-2(3H)-ones (3) with thallium(III) nitrate to 1-methyl 2-arylsucc
