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3-Methoxy-14-acetoxy-17-methyl-4,5α-epoxy-7,8-didehydromorphinan-6-one is a complex organic compound belonging to the morphinan class, which is derived from morphine. This specific compound features a 7,8-didehydro structure, indicating the absence of two hydrogen atoms between carbon atoms 7 and 8, and a 4,5α-epoxy bridge, which is a three-membered oxygen-containing ring. The molecule also contains a 3-methoxy group, which is a methoxy group attached to the third carbon, and a 14-acetoxy group, which is an acetoxy group attached to the fourteenth carbon. Additionally, it has a 17-methyl group, indicating a methyl group attached to the seventeenth carbon. 3-Methoxy-14-acetoxy-17-methyl-4,5α-epoxy-7,8-didehydromorphinan-6-one is known for its potent analgesic properties and is structurally similar to other opioids, although its specific pharmacological effects and applications may vary.

978-76-7

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978-76-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 978-76-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,7 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 978-76:
(5*9)+(4*7)+(3*8)+(2*7)+(1*6)=117
117 % 10 = 7
So 978-76-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H21NO5/c1-11(22)26-20-7-6-13(23)18-19(20)8-9-21(2)15(20)10-12-4-5-14(24-3)17(25-18)16(12)19/h4-7,15,18H,8-10H2,1-3H3/t15-,18+,19+,20-/m1/s1

978-76-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name [(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-7-oxo-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl] acetate

1.2 Other means of identification

Product number -
Other names Codeinone,14-hydroxy-,acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:978-76-7 SDS

978-76-7Relevant academic research and scientific papers

PROCESSES FOR PREPARING NOR-OPIOID COMPOUNDS AND OPIOID ANTAGONISTS BY ELECTROCHEMICAL N-DEMETHYLATION

-

, (2021/12/31)

The present invention relates to a process for preparing a nor-opioid compound wherein an opioid precursor compound is electrochemically N-demethylated. The present invention further relates to a process for preparing an opioid antagonist compound, wherein an opioid precursor compound is electrochemically N-demethylated and the thus obtained nor-opioid compound is alkylated again at its secondary amine functional group.

Electrochemical N-Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists

Cantillo, David,Glotz, Gabriel,Kappe, C. Oliver

, p. 6891 - 6896 (2020/09/15)

The most challenging step in the preparation of many opioid antagonists is the selective N-demethylation of a 14-hydroxymorphinan precursor. This process is carried out on a large scale using stoichiometric amounts of hazardous chemicals like cyanogen bromide or chloroformates. We have developed a mild reagent- and catalyst-free procedure for the N-demethylation step based on the anodic oxidation of the tertiary amine. The ensuing intermediates can be readily hydrolyzed to the target nor-opioids in very good yields.

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