97816-39-2Relevant academic research and scientific papers
A domino Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines and application to the synthesis of the ceramide transport inhibitor (±)-HPA-12
Legendre, Sarah V.A.-M.,Jevric, Martyn,Klepp, Julian,Sumby, Christopher J.,Greatrex, Ben W.
, p. 1229 - 1239 (2018)
A Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines with primary and secondary amines has been developed which affords 4-hydroxy-3-aminoketones. The aza-Michael products were reduced using non-selective NaBH4/MeOH or diastereoselective (up to 92:8) SnCl4/NaBH4 conditions yielding (1R?,3S?)-3-amino-1,4-diols in up to 97% and 70% yield respectively. The major reduction product was converted in two steps to (±)-HPA-12, which is an inhibitor of the cytosolic ceramide transporting protein.
ROSE BENGAL DERIVATIVES AS SINGLET OXYGEN SENSITIZERS
Lamberts, J. J. M.,Neckers, D. C.
, p. 2183 - 2190 (2007/10/02)
Derivatives of Rose Bengal are reported and the relationships between subtle structural and dramatic changes in photophysical properties pointed out.
