97829-55-5

Upstream product

• 92967-67-4 1,2-bis(4-cyanophenyl)ethane-1,2-dione 
• 95-54-5 1,2-diamino-benzene 
• 3058-39-7 4-iodobenzonitrile 
• 3032-92-6 4-cyanophenylacetylene 
• 1190987-69-9 C₁₆H₁₀N₂O₂ 
• 105-07-7 4-cyanobenzaldehyde 

Relevant academic research and scientific papers

Sequentially Pd/Cu-Catalyzed Alkynylation-Oxidation Synthesis of 1,2-Diketones and Consecutive One-Pot Generation of Quinoxalines

We report a simple and efficient one-pot synthesis of 1,2-diketones by concatenation of two Pd/Cu-catalyzed processes: Pd0/CuI-catalyzed Sonogashira coupling of terminal alkynes with aryl (pseudo)halides furnishes internal alkynes, which are directly transformed by PdII/CuII-catalyzed Wacker-type oxidation with DMSO and oxygen as dual oxidants to furnish 1,2-diketones. With this efficient, catalyst economical process, various aryl iodides and triflates are efficiently transformed in high yields into symmetrically and unsymmetrically substituted 1,2-diketones with various functional groups. This process can be readily extended to a consecutive one-pot synthesis of quinoxalines in a diversity-oriented fashion.

One-pot synthesis of quinoxalines starting from aldehydes under metal-free conditions

An efficient and convenient synthesis of quinoxalines from easily available aldehydes was performed as a one-pot procedure in good to excellent yields under metal-free conditions, via sequential benzoin condensation, aerobic formation of benzils and condensation of the latter with 1,2-diaminobenzenes.