97840-77-2Relevant articles and documents
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Pau,J.K. et al.
, p. 3838 - 3846 (1978)
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QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT
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Page/Page column 35, (2009/10/22)
This invention relates to novel quinazoline derivatives, and their pharmaceutically acceptable salts. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and con
Are Tetrahedral Intermediates Formed by Addition of Nucleophiles to Organoboranes in the Gas Phase?
Currie, Graeme J.,Bowie, John H.,Downard, Kevin M.,Sheldon, John C.
, p. 1973 - 1980 (2007/10/02)
Nucleophilic addition of CD3O- to Me2BOMe gives the same addition product as the corresponding reaction between Me2BOCD3 and MeO-, as evidenced by the identical collisional activation mass spectra of the products.This is interpreted in terms of exclusive formation of a boron product ion of terahedral geometry.The decompositions of the product involve loss of MeOH and CD3OH and the formation of MeO- and CD3O-.The major decompositions of (CD3)3B+-OCH2CH2XMe (X=O, S, or NMe2) are similar to those outlined above and may be explained by initial formation of (CD3)3B-OCH2CH2XMe.However, there are some unusual fragmentations (e.g. loss of CH3D) which may occur through the alternative structure (CD3)3B-X+(Me)CH2CH2O-.It is suggested the other ambident species may also react with Me3B to form several tetrahedral species, e.g. deprotonated methyl acetate could yield Me3B-CH2CO2Me, Me3B-OC(OMe)=CH2, and Me3B--O+(Me)CCH2O-.The formation of the third structure is supported by the pronounced loss of ketene from this system.
