97847-73-9Relevant academic research and scientific papers
Nonacarbonyldiiron-, Pentacarbonyliron-, or Hexacarbonylmolybdenum-induced Reactions of 4,5-Polymethylene-substituted 2-Isoxazolines
Nitta, Makoto,Yi, Akihiro,Kobayashi, Tomoshige
, p. 991 - 994 (1985)
The reaction of 4,5-polymethylene-substituted 2-isoxazolines, 3-phenyl-3a,5,6,7a-tetrahydro-4H-pyranoisoxazole or 3-phenyl-3a,4,5,6a-tetrahydrofuroisoxazole, with , , or resulted in the formation of 5-hydroxy-1-phenyl-1-pentanone or 4-hydroxy-1-phenyl-1-butanone, via the N-O and C-C bond cleavage of the 2-isoxazoline ring and the subsequent hydrolysis.The similar reaction of 7a-morpholino- and 7a-(1-pyrrolidinyl)-3-phenyl-3a,4,5,6,7,7a-hexahydro-1,2-benzoisoxazoles undergoes the N-O bond cleavage and, the subsequent elimination of the amino group or the C-3a-C-7a bond fission.Although the reaction of 6a-morpholino- and 6a-(1-pyrrolidinyl)-3-phenyl-3a,4,5,6a-tetrahydro-4H-cyclopentisoxazoles with undergoes the N-O bond cleavage, and the subsequent elimination of the amino group or the C-3a-C-6a bond fission, the reaction of those 2-isoxazolines with proceeds very slowly.The mechanisms are proposed for these reactions.
6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: Novel HIV protease inhibitors
Hamilton, Harriet W.,Tait, Bradley D.,Gajda, Christopher,Hagen, Susan E.,Ferguson, Donna,Lunney, Elizabeth A.,Pavlovsky, Alexander,Tummino, Peter J.
, p. 719 - 724 (2007/10/03)
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones as HIV protease inhibitors. The current work examines the analogues 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the use of 1
