97847-89-7Relevant academic research and scientific papers
Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp3)-H and δ-C-H Bonds with an Oxazoline-Carboxylate Auxiliary
Ling, Peng-Xiang,Fang, Sheng-Long,Yin, Xue-Song,Chen, Kai,Sun, Bo-Zheng,Shi, Bing-Feng
supporting information, p. 17503 - 17507 (2016/01/25)
A palladium-catalyzed arylation of unactivated γ-methylene C(sp3)-H and remote δ-C-H bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.
SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS
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Paragraph 20; 39; 48, (2015/12/31)
The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
1-DIPHENYLPHOSPHINYL-2,2-DIMETHYLAZIRIDINE - A NEW PRECURSOR OF α,α-DIMETHYLARYLALKYLAMINES
Buchowiecki, Wieslaw,Grosman-Zjawiona, Zofia,Zjawiony, Jordan
, p. 1245 - 1248 (2007/10/02)
The new synthesis of α,α-dimethylarylalkylamines from 1-diphenylphosphinyl-2,2-dimethylaziridine is described.
