97911-72-3

Upstream product

• 97911-69-8 Benzoic acid 6-[(S)-((1R,4S,7R,8R,9S)-5-hydroxy-7-methoxy-10-methyl-2-oxo-6-oxa-3,10-diaza-tricyclo[6.2.1.0^4,9]undec-3-yl)-methoxycarbonyl-methyl]-2,4-dimethoxy-3-methyl-phenyl ester 
• 97911-71-2 Benzoic acid 6-[(S)-((1R,4S,5R,7R,8R,9S)-5-chloro-7-methoxy-10-methyl-2-oxo-6-oxa-3,10-diaza-tricyclo[6.2.1.0^4,9]undec-3-yl)-methoxycarbonyl-methyl]-2,4-dimethoxy-3-methyl-phenyl ester 

Relevant academic research and scientific papers

THE TOTAL SYNTHESIS OF (+/-)-NAPHTHYRIDINOMYCIN. II. CONSTRUCTION OF THE PENTACYCLIC CARBON SKELETON.

A synthesis of an advanced pentacyclic intermediate to the quinone antibiotic naphthyridinomycin (1) is described.The stereoselective synthesis of 2b from tricyclic lactam 3 features a regio- and stereoselective, intermolecular amidoalkylation reaction and a Friedel-Crafts ring closure to annelate the aromatic nucleus.