97961-94-9

Upstream product

• 13141-50-9 2’-methylspiro[cyclohexane-1,3’-(3’H)-indole] 
• 95-20-5 2-methyl-1H-indole 
• 628-77-3 1,5-diiodopentane 
• 171-74-4 Spiroindole> 
• 74-88-4 methyl iodide 
• 917-54-4 methyllithium 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 1620581-48-7 2-isobutyl-2-(2-methoxy-5-((2'-methylspiro[cyclohexane-1,3'-indolin]-1'-yl)sulfonyl)phenyl)-4-methylpentanenitrile 
• 1620581-54-5 2-(2,4-dichloro-5-((2'-methylspiro[cyclohexane-1,3'-indolin]-1'-yl)sulfonyl)phenyl)-2-isobutyl-4-methylpentanenitrile 

Relevant academic research and scientific papers

Transfer hydrogenation of nitrogen heterocycles using a recyclable rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica

Transfer hydrogenation of unsaturated nitrogen heterocycles using a rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica (BPy-PMO) is described. The immobilized catalyst was prepared by mixing [Cp?RhCl2]2 (Cp?

New hexahydrocarbazoles and spiro indoles, and their affinity for D2 dopamine and 5-HT(2A) serotonin receptors

In a search for novel atypical antipsychotics, the synthesis of new hexahydrocarbazoles and spiro indoles N-substituted with a 3- (dimethylamino)propyl chain is described, together with the results of an in vitro evaluation of their affinities for D2

Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides

Unfunctionalized indoles can be directly converted into 3,3′-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This double C-C bond forming reaction, which simultaneously generates a quaternary spirocyclic center, typically proceeds in high yield and has good functional group tolerance. In contrast to existing dearomatizing spirocyclization approaches, there is no need to prepare a prefunctionalized aromatic precursor, enabling faster access to valuable spirocyclic products from simple, commercially available aromatics in one step.

SYNTHESIS OF 1'-(3-DIMETHYLAMINOPROPYL)-2'-SUBSTITUTED SPIRO.

Reactivity of the C=N bond in spiro has been analysed.Indolines were obtained in practically quantitative yield using organomagnesium reagents in the presence of copper(I) chloride in toluene at 120 deg C.On the basis of an an

REACTION OF SPIRO WITH GRIGNARD REAGENTS IN THE PRESENCE OF CUPROUS CHLORIDE

Attack of MeMgI and PhMgBr in toluene on spiro (1) in the presence of Cu2Cl2 gives 2'-substituted spiro in quantitative yields.Also, attack of PhCH2CH2MgBr on 1 in the presence of Cu2Cl2 afforded 2'-phenethyl, 2'-H and 2'-benzyl (or 2'-p-xylyl) derivatives in toluene (or p-xylene) as solvent.