97963-58-1 Usage
Chemical core
1H-Benzimidazole
A heterocyclic aromatic ring system consisting of a central nitrogen atom bonded to two carbon atoms, with one additional carbon atom attached to the nitrogen.
Fluoromethoxy group
5-(difluoromethoxy)
A methoxy group (-OCH3) with two hydrogen atoms replaced by fluorine atoms (-CF2H), attached to the benzimidazole core at the 5-position.
Methoxy group
6-methoxy
An oxygen atom bonded to a methyl group (-OCH3), attached to the benzimidazole core at the 6-position.
Thiomethyl group
2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-
A sulfur atom bonded to a methyl group (-CH3), attached to the benzimidazole core at the 2-position through a pyridinylmethyl group.
Pyridinylmethyl group
2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-
A methyl group (-CH3) bonded to a 2-pyridinyl ring system, which is further substituted with a methoxy group at the 4-position and a methyl group at the 3-position.
Potential applications
Pharmaceuticals
Benzimidazole compounds are known for their diverse pharmacological activities, such as anti-cancer and anti-inflammatory properties.
Unique biological activities
Specific substitution pattern
The combination of fluoromethoxy, methoxy, thiomethyl, and pyridinylmethyl groups in this compound may contribute to its distinct biological activities and potential therapeutic use.
Check Digit Verification of cas no
The CAS Registry Mumber 97963-58-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,9,6 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 97963-58:
(7*9)+(6*7)+(5*9)+(4*6)+(3*3)+(2*5)+(1*8)=201
201 % 10 = 1
So 97963-58-1 is a valid CAS Registry Number.
97963-58-1Relevant articles and documents
(H+,K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate
Kohl,Sturm,Senn-Bilfinger,Simon,Kruger,Schaefer,Rainer,Figala,Klemm
, p. 1049 - 1057 (2007/10/02)
[(Pyridylmethyl)sulfinyl]benzimidazoles 1 (PSBs) are a class of highly potent antisecretory (H+,K+)-ATPase inhibitors which need to be activated by acid to form their active principle, the cyclic sulfenamide 4. Selective inhibitors of the (H+,K+)-ATPase in vivo give rise to the nonselective thiophile 4 solely at low pH, thus avoiding interaction with other thiol groups in the body. The propensity to undergo the acid-catalyzed transformation is dependent on the nucleophilic/electrophilic properties of the functional groups involved in the formation of 2 since this step is both rate-determining and pH-dependent. The aim of this study was to identify compounds with high (H+,K+)-ATPase inhibitory activity in stimulated gastric glands possessing acidic pH, but low reactivity (high chemical stability) at neutral pH as reflected by in vitro (Na+,K+)-ATPase inhibitory activity. The critical influence of substituents flanking the pyridine 4-methoxy substituent present in all derivatives was carefully studied. The introduction of a 3-methoxy group gave inhibitors possessing a combination of high potency, similar to omeprazole and lansoprazole, but increased stability. As a result of these studies, compound 1a (INN pantoprazole) was selected as a candidate drug and is currently undergoing phase III clinical studies.
