97968-19-9

Upstream product

• 1217438-35-1 1,1-bis(4-methoxyphenyl)propan-2-one O-acetyl oxime 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 39232-91-2 m-methoxyphenylhydrazine hydrochloride 

Downstream Products

• 97968-34-8 Acetic acid 3-(4-acetoxy-phenyl)-1-ethyl-2-methyl-1H-indol-6-yl ester 
• 97968-33-7 Acetic acid 3-(4-acetoxy-phenyl)-1,2-dimethyl-1H-indol-6-yl ester 
• 97968-24-6 6-Methoxy-3-(4-methoxy-phenyl)-1,2-dimethyl-1H-indole 
• 97968-25-7 1-Ethyl-6-methoxy-3-(4-methoxy-phenyl)-2-methyl-1H-indole 

Relevant academic research and scientific papers

Palladium-catalyzed amination of aromatic C-H bonds with oxime esters

"Chemical equation presented" We report a conceptually new approach to the direct amination of aromatic C-H bonds. In this process, an oxime ester function reacts with an aromatic C-H bond under redox-neutral conditions to form, in the case studied, an indole product. These reactions occur with relatively low catalyst loading (1 mol %) by a mechanism that appears to involve an unusual initial oxidative addition of an N-O bond to a Pd(0) species. The Pd(II) complex from oxidative addition of the N-X bond has been isolated for the first time, and evidence for the intermediacy of such oxidative addition products in the catalytic reaction has been gained.