980-71-2 Usage
Description
Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.
Chemical Properties
White Solid
Originator
Dimetane,Robins,US,1957
Uses
Different sources of media describe the Uses of 980-71-2 differently. You can refer to the following data:
1. This drug is only available in combination with other
medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist.
The only difference between this agent and chlorpheniramine is the substitution
of a bromine for a chlorine atom in brompheniramine.
2. An antihistamine and also an inhibitor of serotonin reuptake
Definition
ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Manufacturing Process
Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2-
chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted
with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl-
pyridyl acetonitrile. This intermediate is then hydrolyzed
and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for
24 hours. The brompheniramine maleate may be made by reaction with
maleic acid in ethanol followed by recrystallization from pentanol.
General Description
Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
Side effects
The side effects of this
medication are similar to other classes of sedative antihistamines. Some medications
include parabens. Patients sensitive to parabens may develop a sensitivity
reaction.
Check Digit Verification of cas no
The CAS Registry Mumber 980-71-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 0 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 980-71:
(5*9)+(4*8)+(3*0)+(2*7)+(1*1)=92
92 % 10 = 2
So 980-71-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
