98007-99-9

Upstream product

• 2834-05-1 11-bromoundecanoic acid 
• 153004-18-3 11-((6R,7S,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)-undecanoic acid butyl-methyl-amide 
• 153004-17-2 11-((6R,7R,8R,9S,13S,14S,17S)-6-Benzenesulfonyl-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)-undec-10-ynoic acid butyl-methyl-amide 
• 1611-56-9 1-Bromo-11-hydroxyundecane 
• 862700-67-2 11-(3,17β-di(tetrahydropyranyloxy)-6-keto-estra-1,3,5(10)-triene-7α-yl)-undecanoic acid n-butyl-methyl-amide 
• 98008-50-5 11-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)undecanoic acid 
• 125151-25-9 17β-Acetoxy-3-benzoyloxy-7α-(11-hydroxyundecyl)estra-1,3,5(10)-triene 
• 98008-54-9 17β-Acetoxy-7α-(11-dimethyl-t-butylsilyloxyundecyl)estr-4-en-3-one 
• 55592-08-0 17β-Acetoxy-7α-(11-acetoxyundecyl)estr-4-en-3-one 
• 98008-56-1 17β-Acetoxy-7α-(11-acetoxyundecyl)estra-1,3,5(10)-trien-3-ol 
• 98008-57-2 17β-Acetoxy-7α-(11-hydroxyundecyl)estra-1,3,5(10)-trien-3-ol 
• 98008-53-8 11-(dimethyl-t-butylsilyloxy)undecyl bromide 
• 2590-41-2 6-dehydro-19-nortestosterone acetate 
• 156137-94-9 Acetic acid (8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6-phenylsulfanyl-9,11,12,13,14,15,16,17-octahydro-8H-cyclopenta[a]phenanthren-17-yl ester 

Relevant academic research and scientific papers

STEROIDS FOR CANCER TREATMENT

The present invention relates to novel compounds which are 7α-substituted 17-alkylene-16α-hydroxy steroidal estrogens. This invention specifically relates to estrogen derivatives which contain 7α-substituents and which exhibit anti-estrogenic properties. The present invention also relates to use of said compounds as a medicament, and for the treatment of estrogen dependent disorders, a pharmaceutical composition comprising one or more of said compounds and a method of treatment.

An expeditious route to 7α-substituted estradiol derivatives

6-Ketoestradiol derivatives are converted in 7α-alkyl substituted estradiol derivatives selectively by alkylation of the generated enolate followed by deoxygenation-deprotection with BF3·Et2O/Et3SiH.

A NEW, STEREOSELECTIVE APPROACH TO C(7)-ALKYLATED ESTRA-1,3,5(10)-TRIENE DERIVATIVES

17β-Acetyloxy-3-methoxy-6-(phenylsulfonyl)estra-1,3,5(10),6-tetraene (4) was prepared as a substrate for conjugate addition of organolithium reagents by a three-step sequence starting from 17β-acetyloxy-3-methoxyestra-1,3,5(10)-trien-6-one (2).While methy