98010-71-0Relevant academic research and scientific papers
Structure-activity relationship of s-triazoles and thiadiazoles as analgesics
Siwek, Agata,Wujec, Monika,Plech, Tomasz,KuSmierz, Edyta,Jagielo-Wojtowicz, Ewa,Chodkowska, Anna
experimental part, p. 256 - 264 (2011/07/07)
The influence of s-triazoles (6-9)and thiadiazoles (10-11) on the central nervous system of mice in some behavioral tests was investigated. It was found that compounds (10)and (11) are the possible candidates for further development as analgesic agents. The correlation between the molecular descriptors and analgesic potential has been studied by using the pattern recognition methods: principal component analysis (PCA) and hierarchical cluster analysis (HCA). Our results, however, showed that the relationship between molecular descriptors and analgesic activity of s-triazoles and thiadiazoles cannot be easily explained on the basis of PCA and HCA.
