98019-60-4

Basic information

• Product Name: 5-ISOXAZOLEMETHANOL
• Synonyms: AKOS PAO-1429;5-ISOXAZOLEMETHANOL;ISOXAZOL-5-YL-METHANOL;5-(Hydroxymethyl)isoxazole;1,2-Oxazol-5-ylmethanol
• CAS NO: 98019-60-4
• Molecular Formula: C₄H₅NO₂
• Molecular Weight: 99.09
• Mol File: 98019-60-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 115-125 °C(Press: 16 Torr)
• Appearance: /
• Density: 1.250
• Storage Temp.: 2-8°C
• PKA: 13.41±0.10(Predicted)
• CAS DataBase Reference: 5-ISOXAZOLEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ISOXAZOLEMETHANOL(98019-60-4)
• EPA Substance Registry System: 5-ISOXAZOLEMETHANOL(98019-60-4)

Safety Data

• Hazardous Substances Data: 98019-60-4(Hazardous Substances Data)

Usage

General Description

5-ISOXAZOLEMETHANOL, also known as isoxazol-5-ol, is a heterocyclic compound with the molecular formula C3H4N2O2. It is a colorless, crystalline solid with a melting point of 155-157°C. This chemical is primarily used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It possesses an isoxazole ring, which makes it a useful intermediate in the production of various drugs and biologically active molecules. Additionally, 5-ISOXAZOLEMETHANOL can act as a heterocyclic bifunctional reagent in organic synthesis, enabling the formation of other complex chemical structures. Due to its versatile nature and importance in organic chemistry, this compound is of interest to researchers and manufacturers in the pharmaceutical and agrochemical industries.

Upstream product

• 15736-98-8 sodium cyanate 
• 107-19-7 propargyl alcohol 
• 99805-29-5 4-tetrahydropyran-2-yloxy-but-2-ynal-diethylacetal 
• 7664-93-9 sulfuric acid 
• 21169-71-1 isoxazole-5-carboxylic acid 
• 173850-41-4 5-isoxazolecarboxylic acid ethyl ester 

Downstream Products

• 21169-71-1 isoxazole-5-carboxylic acid 
• 144186-59-4 ((5-Isoxazolyl)methyl)-(4-nitrophenyl)carbonate 
• 69735-35-9 5-bromomethyl isoxazole 
• 57777-33-0 5-(chloromethyl)isoxazole 
• 16401-14-2 5-isoxazolecarboxaldehyde 

Relevant articles and documents

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

NOVEL ANDROGENS

The compounds of the subject invention have a structure according to formula I: wherein X is S or SO2; R1 is (1C-6C)alkyl, (3C-6C)alkenyl, or (3C-6C)alkynyl, each optionally subst ituted with (3C-6C)cycloalkyl, OH, OC(O)(1C-4C)alkyl, (1C- 4C)alkoxy, halogen, cyano, formyl, C(O)(1C-4C)alkyl, CO2H, CO2(1C- 4C)alkyl, C(O)NR5R6, S(O)(1C-4C)alkyl or S(O)2(1C-4C)alkyl; R2 is hydrogen, (1C-4C)alkyl or C(O)(1C-4C)alkyl; R3 is a phenyl group optionally substituted with (1C-4C)alkyl, (1C-4C)fluoroalkyl, (1C-4C)alkoxy, (1C-4C)fluoroalkoxy, halogen, cyano or nitro; or R3 is a 5- or 6-membered aromatic heterocyclic ring structure optionally substituted with (1C-4C)alkyl, (1C-4C)fluoroalkyl, (1C-4C)alkoxy, halogen or cyano; R4 is a phenyl group or an aromatic 6-membered heterocycle, substituted at the ortho position with 1-hydroxy(1C-4C)alkyl, (1C-4C)alkoxy, C(O)(1C- 4C)alkyl, CO2(1C-4C)alkyl, C(O)NH2, cyano, nitro, or CH=NOR7, and optionally further substituted with (1C-2C)alkyl, (1C-2C)fluoroalkyl or halogen; R5 is 2-pyridyl optionally substituted with (1C-2C)alkyl, (1C- 2C)fluoroalkyl or halogen; or R5 and R6 are independently hydrogen or (1C-4C)alkyl; R7 is hydrogen or C(O)(1C-4C)alkyl; R8 , R9 , R10 are independently hydrogen, (1C-2C)alkyl, fluoro or chloro; or a salt or hydrate form thereof.

Regioisomeric 3-, 4- and 5-aminomethyl isoxazoles: Synthesis and muscarinic activity

A series of 3-, 4- and 5-aminomethyl isoxazoles and isoxazoles with one or two additional methyl groups at the heterocycle were synthesized in order to investigate the structural requirements, ie heterocyclic moiety, regiochemistry and length of an aminoalkyl unit, for muscarinic activity. This was assayed on isolated rabbit vas deferens (M1 receptor subtype) and isolated guinea-pig atrium (M2 receptor subtype) and ileum (M3 receptor subtype). The isoxazoles tested are one to three orders of magnitude less active than furane or oxadiazole derivatives, having similar structural characteristics except for the heterocycle. Thus, the differences in molecular point charges and charge distribution contribute to the muscarinic activity of these compounds more than small differences in molecular shape and conformational energies.