98021-95-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-4-hydrazino-5-methoxy-pyrimidine is used as an intermediate in the synthesis of various complex compounds, particularly within the pharmaceutical industry. Its unique structure and functional groups make it a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 2-Chloro-4-hydrazino-5-methoxy-pyrimidine serves as a valuable compound for studying the properties and reactivity of pyrimidine-based structures. Its functional groups allow for the exploration of various chemical reactions and the development of novel synthetic pathways.
Used in Biochemical Studies:
Due to its structural similarity to DNA nucleotides, 2-Chloro-4-hydrazino-5-methoxy-pyrimidine can be used in biochemical studies to investigate the interactions between pyrimidine-based compounds and biological systems. This can provide insights into the mechanisms of action of certain drugs and help in the design of more effective therapeutic agents.
Used in Material Science:
The unique properties of 2-Chloro-4-hydrazino-5-methoxy-pyrimidine, such as its stability and solubility, make it a potential candidate for use in material science applications. It could be incorporated into the development of new materials with specific properties, such as sensors, catalysts, or advanced materials for various industries.

Upstream product

• 19646-07-2 2,4-dichloro-5-methoxypyrimidine 

Downstream Products

• 219715-62-5 2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine 
• 1956386-49-4 2-chloro-4-[2-(2-chloro-5-methoxy-4-pyrimidinyl)hydrazinyl]-5-methoxypyrimidine 

Relevant academic research and scientific papers

Preparation method of penoxsulam original medicine related impurity bis-CHYMP

The invention provides a preparation method of penoxsulam original medicine related impurity bis-CHYMP, which comprises the following steps of: 1, dissolving 2, 4-dichloro-5-methoxy pyrimidine in methanol, adding triethylamine, adding hydrazine hydrate, carrying out reflux reaction, monitoring the reaction by TLC until the reaction is completed, cooling to room temperature, purifying to obtain 2-chlorine-5-methoxy-4-hydrazinylpyrimidine; 2, dissolving 2-chlorine-5-methoxy-4-hydroxypyrimidine in methanol, adding triethylamine, slowly dropping 2, 4-dichloro-5-methoxy pyrimidine methanol solution, carrying out reflux reaction, detecting the reaction by LCMS until the reaction is completed, cooling to obtain mixed liquid; 3, extracting, washing and concentrating the mixed liquid, preparing high performance liquid phase and purifying to obtain 2-chlorine-4-[2-(2-chlorine-5-methoxy-4-pyrimidine base) hydrazino]-5-methoxy pyrimidine; the synthetic route is shown in the description. The methodhas the advantages of economic feasibility and high yield.

Process for the preparation of 2-amino-5, 8-dimethoxy (1,2,4) triazolo (1,5-c) pyrimidine

2-Amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]-pyrimidine is prepared from a 5-chloro or 5-methoxy substituted 3-amino-8-methoxy[1,2,4]triazolo[4,3-c]-pyrimidine by reaction with methoxide in an alcohol solvent. Both rearrangement and, when the 5-substituent is chloro, methoxy substitution can be accomplished directly.

Process for the preparation of 2-amino-5,8-dimethoxy(1,2,4)triazolo(1,5c)pyrimidine

2-Amino-5, 8-dimethoxy[1,2,4]triazolo[1,5-c]-pyrimidine is prepared from a 5-chloro or 5-methoxy substituted 3-amino-8-methoxy[1,2,4]triazolo[4,3-c]-pyrimidine by reaction with methoxide in an alcohol solvent. Both rearrangement and, when the 5-substituent is chloro, methoxy substitution can be accomplished directly.