98021-95-5

Basic information

• Product Name: 2-Chloro-4-hydrazino-5-methoxy-pyrimidine
• Synonyms: 2-Chloro-4-hydrazino-5-methoxy-pyrimidine;(2-Chloro-5-Methoxy-pyriMidin-4-yl)-hydrazine;2-chloro-4-Hydrazino-5-MethoxypyriMdine;2-Chloro-4-hydrazinyl-5-methoxypyrimidine
• CAS NO: 98021-95-5
• Molecular Formula: C₅H₇ClN₄O
• Molecular Weight: 174.59
• Mol File: 98021-95-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 148-150℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Chloro-4-hydrazino-5-methoxy-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-hydrazino-5-methoxy-pyrimidine(98021-95-5)
• EPA Substance Registry System: 2-Chloro-4-hydrazino-5-methoxy-pyrimidine(98021-95-5)

Safety Data

• Hazardous Substances Data: 98021-95-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-hydrazino-5-methoxy-pyrimidine is a chemical compound with the formula C5H6ClN5O. It is primarily known for its use in the synthesis of other complex compounds, particularly within the pharmacological space. The substance is characterized by its pyrimidine ring, a six-member structure containing two nitrogen atoms and four carbon atoms, which is a fundamental element in many significant biological compounds like nucleotides of DNA. Its additional functional groups, including a chloro group, a hydrazino group, and a methoxy group, significantly influence its reactivity and contribute to its potential multi-functionality in chemical synthesis and pharmaceutical applications. Furthermore, the properties such as stability, solubility, and toxicity are also crucial for its application purpose, which varies according to specific conditions and usage.

Upstream product

• 19646-07-2 2,4-dichloro-5-methoxypyrimidine 

Downstream Products

• 219715-62-5 2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine 
• 1956386-49-4 2-chloro-4-[2-(2-chloro-5-methoxy-4-pyrimidinyl)hydrazinyl]-5-methoxypyrimidine 

Relevant articles and documents

Preparation method of penoxsulam original medicine related impurity bis-CHYMP

The invention provides a preparation method of penoxsulam original medicine related impurity bis-CHYMP, which comprises the following steps of: 1, dissolving 2, 4-dichloro-5-methoxy pyrimidine in methanol, adding triethylamine, adding hydrazine hydrate, carrying out reflux reaction, monitoring the reaction by TLC until the reaction is completed, cooling to room temperature, purifying to obtain 2-chlorine-5-methoxy-4-hydrazinylpyrimidine; 2, dissolving 2-chlorine-5-methoxy-4-hydroxypyrimidine in methanol, adding triethylamine, slowly dropping 2, 4-dichloro-5-methoxy pyrimidine methanol solution, carrying out reflux reaction, detecting the reaction by LCMS until the reaction is completed, cooling to obtain mixed liquid; 3, extracting, washing and concentrating the mixed liquid, preparing high performance liquid phase and purifying to obtain 2-chlorine-4-[2-(2-chlorine-5-methoxy-4-pyrimidine base) hydrazino]-5-methoxy pyrimidine; the synthetic route is shown in the description. The methodhas the advantages of economic feasibility and high yield.

Process for the preparation of 2-amino-5, 8-dimethoxy (1,2,4) triazolo (1,5-c) pyrimidine

2-Amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]-pyrimidine is prepared from a 5-chloro or 5-methoxy substituted 3-amino-8-methoxy[1,2,4]triazolo[4,3-c]-pyrimidine by reaction with methoxide in an alcohol solvent. Both rearrangement and, when the 5-substituent is chloro, methoxy substitution can be accomplished directly.